Pediatric Oncology
Education Materials

SYSTEM

SIDE EFFECT

Early:

• Anemia/Leukopenia
• Thrombocytopenia

• Most agents (exceptions: vincristine, steroids)

Late:

• Secondary leukemia

• Alkylating agents
• Etoposide

Early:

• Mood alterations

• Steroids

Late: Peripheral NS

• Neurotoxicity

• Vincristine
• Cisplatin

Late: CNS

• Leukoencephalopathy

• Methotrexate (sometimes alone without RT)

Late:

• Ototoxicity

• Cisplatin and carboplatin

• Cardiomyopathy

• Daunorubicin/doxorubicin
• Cyclophosphamide (high dose)

• Fibrosis

• Bleomycin, mitomycin, carmustine

• Infertility

• Nitrogen mustard
• Cyclophosphamide

• Teratogenic

• Retinoids
• Thalidomide
• Antimetabolites
• Alkylating agents
• Vinca alkaloids
• Topoisomerase II inhibitors

Early:

• Nausea and vomiting
• Anorexia (dose related)

Many drugs especially:

• Cisplatin
• Cytosine arabinoside
• Cyclophosphamides
• Anthracyclines

• Diarrhea

• Irinotecan
• Cisplatin

• Constipation

• Vincristine
• Thalidomide

• Mucositis

• Methotrexate
• Daunorubicin
• Doxorubicin

• Hepatoxicity

• 6-MP
• 6-TG
• Etoposide (VP-16)
• Cytosine arabinoside

• Pancreatitis

• Asparaginase
• Steroids

Early:

• Hemorrhagic cystitis

Late:

• Bladder carcinoma

• Cyclophosphamide
• Ifosfamide

• Renal

• Cisplatin & Carboplatin

• Anaphylaxis

• Asparaginase

• Allergic reaction

• Carboplatin
• Etoposide
• Bleomycin

• Hypotension

• Etoposide

• Alopecia

Most drugs cause this

(Exceptions: steroids, retinoids & antiangiogenics)

• Acne

• Steroids
• Actinomycin

• Rash

• Cytosine arabinoside

• Striae

• Steroids

• Photosensitivity

• Methotrexate
• Retinoids

• Radiomimetic

• Actinomycin
• Daunorubicin
• Doxorubicin

• Hyperpigmentation

• Bleomycin
• Busulfan

• Extravasation (Vesicants)

• Actinomycin
• Daunorubicin
• Doxorubicin
• Mechlorethamine
• Mitomycin
• Vinblastine, vincristine & vinorelbine