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Peripheral Nervous System


Therapy for Peripheral Neuropathy


There is no treatment that effectively reverses peripheral neuropathy3, but there are steps that can be taken to prevent or reduce its occurrence, and to manage the symptoms.



  • Treat underlying exacerbating conditions eg. Vitamin B12 deficiency and diabetes
  • Monitor potential for toxic synergy with other concurrent drug therapies
  • Use of cytoprotective drugs (eg. Glutamine for paclitaxel, amifostine for cisplatin)



  • Physiotherapy with exercises can improve strength, balance and coordination
  • Occupational therapy can also help with adaptations to live with the neuropathy
  • Orthotic devices can be helpful with support for feet and ankles
  • Arch supports and splints can help to prevent the arch of the foot from flattening and may help with walking
  • Medications such as antidepressants and anticonvulsants may help to improve the pain and burning sensation.

Alternative non-medical therapies include exercise, hydrotherapy, massage therapy, and vitamin therapy which may improve the patient’s perceived quality of life.



Patient guides:

Children's Oncology Group Guidelines for Survivors: Peripheral Neuropathy

American Cancer Society: Peripheral neuropathy caused by chemotherapy



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