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Late Effects

Second Malignant Neoplasm



The majority of information about survival of patients after the diagnosis of a second malignant neoplasm is from studies of Hodgkin lymphoma survivors.

Survival depends on type of second solid tumor16

  • Median survival was 4.3 years for all types of SMN
  • 5-year overall survival rate of 42.1% for all types of SMN
  • Poorest prognosis for patients with secondary lung cancer (median survival of 1 year).
  • Secondary GI tumor was associated with a 5-year survival rate of 12.4% and median survival, 1.9 years.
  • Breast cancer had a better overall 5-year overall survival rate of 76.1% and the median survival time had not yet been reached.



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