This is a high grade, pleomorphic sarcoma. The pathological classification recently changed of this tumor and it is now referred to as a"pleomorphic undifferentiated sarcoma." The cell of origin is no longer thought to be of histiocytic origin.
Most common soft tissue sarcoma in older adults and very rare in children (25 - 40% of all adult soft tissue sarcoma)
Most common type of sarcoma to arise as a second malignancy after radiation therapy
Often occur in proximal extremities and retroperitoneum
Aggressive disease with metastases to:
- Lung (most common site)
- Liver
- Bone
Pathology
Subclassified into different types:
- Common
- storiform and pleomorphic
- Over 70% of all cases
- Myxoid
- Xantho-granulomatous
- Giant cell
Poor prognosis associated with:
- Deep tumors
- Large tumors (over 10 cm in diameter)
References and Resources:
Malignant Fibrous Histiocytoma: A clinicopathologic Study of 130 cases Munetomo EnjojHiroshi Hashimoto, Masazumi Tsuneyoshi1, Hiroshi IwasakPathology International Volume 30, Issue 5, pages 727–741, September 1980
Arch Pathol Lab Med. 2008 Jun;132(6):1030-5. doi: 10.1043/1543-2165(2008)132[1030:MFHBTP]2.0.CO;2.Malignant fibrous histiocytoma: between the past and the present .Al-Agha OM, Igbokwe AA
