Osteosarcoma (OS) is a primary malignant bone tumor most likely derived from osteoblast precursor cells.
The defining characteristic is a malignant lesion producing osteoid (immature bone) and OS can occur in an extraskeletal location.
There are 2 peaks of incidence, on at ages 10-25 years and then another at ages 50-70 years.
- Occurs slightly earlier in girls (possibly related to earlier growth spurt)
- Accounts for approximately 5% of childhood tumors
- In the US the annual rate is about 5.6/1000,000 white children <15 years old/ year
- Represents 60% of malignant bone tumors in the first 2 decades of life
Summary of Incidence of Osteogenic Sarcoma:
Annual incidence in white population aged under 20 years is 5 - 6 per million
|Proportion of Pediatric Neoplasms||5%|
|Proportion of Primary Bone Tumors||60% of primary bone tumors in children|
10-25 years and 50-70 years
Slightly higher incidence in males
Slightly higher incidence in black populations