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Ewing Sarcoma

 

 

Staging Investigations

 

Currently, there is no internationally recognized staging system for Ewing sarcoma (ES). 

 

A complete work-up for ES is outlined below:

Systemic evaluation

  • History

 

  • Physical examination

 

  • Blood tests (include LDH)

 

Evaluation of extent of primary tumor site

  • Physical examination

 

  • CT – define tumor extent and bone involvement

 

  • MRI – define soft tissue and bone marrow extent

 

  • Planned biopsy

 

Evaluation of metastatic disease

  • Chest CT

 

  • Bone scan

 

  • PET scan (if available)

 

  • Bone marrow aspirate

 

 

 

Blood work should include a baseline lactase dehydrogenase (LDH) level: 

  • An elevated LDH has adverse prognostic significance and suggests very bulky or metastatic disease. 

 

Biopsy

 

Bone Marrow Aspiration Biopsy

  • Essential to stage ES and exclude bone marrow metastases.

 

Imaging investigations

 

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